Formaldehyde formation in the glycine cleavage system and its use for an aldolase-based biosynthesis of 1,3-prodanediol
Abstract Glycine cleavage system (GCS) occupies a key position in one-carbon (C1) metabolic pathway and receives great attention for the use of C1 carbons like formate and CO2 via synthetic biology.In this work, we Fridge Hose Seal demonstrate that formaldehyde exists as a substantial byproduct of the GCS reaction cycle.Three causes are identified